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01 July 2024

Patient-focused Masterclass on YouTube

Our newest Masterclass is now available on YouTube: In her insightful keynote lecture at the 5th QSPAinRelief GA Meeting in Leiden, NL, on 08 December 2023, Deirdre Ryan, President of Pain Alliance Europe (PAE), explains the importance of patient involvement in health-related research, highlighting both the challenges as well as the strategies for meaningful stakeholder engagement. She emphasizes the need for improving patient-reported outcome measures and the mutual benefits of collaboration between patients and researchers. In the QSPainRelief project, chronic pain patients are actively involved in the co-creation of research (e.g. patient questionnaires) and presentation of research outcomes. Watch the full Masterclass on YouTube!

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18-19 June 2024

10th Steering Committee Meeting via Zoom

Summer is here, results are trickling in, and the next publications are forthcoming – Way to go, team! We will soon specify our exploitation strategy to ensure that we engage effectively with chronic pain patients and stakeholders in academia, medicine, and industry! Over 20 attendees, including two scientific and ethical advisory board (SEAB) members, Dr. Petra Bloms-Funke and Jan Freijer, participate in this extended 10th Steering Committee (SC) Meeting on 18-19 June 2024. We also welcome Sonja Leissner from concentris to the project, who will help with the current reporting of our Horizon2020-funded project to the funding agency (European Commission). Great progress despite the pitfalls of the pandemic and the administrative hurdles connected to the clinical trial!

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Personalise and maximize pain relief for individuals suffering from chronic pain

Summary Statement

10 institutions in Europe and the USA collaborate for the next 5 years to help patients suffering from chronic pain. QSPainRelief aims to develop effective drug combination treatments for the improved relief of chronic pain. A quantitative systems pharmacology (QSP) mathematical modelling approach will be used to identify and validate more effective therapeutic interventions by smart combinations of existing drugs. The ultimate goal is to personalise and maximize pain relief for individuals suffering from chronic pain while diminishing side effects.

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  • Consolidating cutting-edge treatment models for chronic pain
  • Summary Statement
  • Validating novel combinational therapies preclinically in vitro and in vivo
  • Conducting clinical studies to detect functional biomarkers
  • Improving the clinical guidelines for pain relief in stratified patient groups
  • Personalising pain relief treatment for each patient
  • Improving the scientific understanding of chronic pain regarding age, sex, disease and genetic factors


  • Novel concepts of combinational pain relief therapies
  • Improved efficacy and acceptability in the clinic
  • Effective stratification of patients with respect to age, sex, disease and genotype
  • Personalised treatment with unswerving benefits for patients
  • Unique knowledge gain and innovation opportunities