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News

15 December 2023

New Masterclasses – watch now on YouTube

When it gets cold and snowy outside this winter, lean back, relax, and watch our newest Masterclasses!

The first one is presented by our scientific coordinator, Prof. Liesbeth de Lange from Leiden University (ULEI) in the Netherlands. The second one is presented by work package 8 (WP8) leader Prof. André Mouraux from UCLouvain (UCL) in Belgium.

We hope you enjoy Liesbeth’s comprehensive story-telling about the decades-long achievements of her research group and about “The miracle of smart data and mathematical modeling in unraveling pharmacokinetic and pharmacodynamic relationships” as well as André’s fascinating overview of “Human biomarkers of nociception”, including recent research results regarding pain perception, and an outlook to the future when we might have tools and methods to prevent, diagnose, and treat chronic pain with a much more personalized approach. Both lectures were recorded within the realm of the 4th General Assembly (GA) Meeting in Barcelona, Spain, on 5 December 2022, and have now been produced for YouTube.

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Events

18-19 June 2024

10th Steering Committee Meeting via Zoom

Summer is here, results are trickling in, and the next publications are forthcoming – Way to go, team! We will soon specify our exploitation strategy to ensure that we engage effectively with chronic pain patients and stakeholders in academia, medicine, and industry! Over 20 attendees, including two scientific and ethical advisory board (SEAB) members, Dr. Petra Bloms-Funke and Jan Freijer, participate in this extended 10th Steering Committee (SC) Meeting on 18-19 June 2024. We also welcome Sonja Leissner from concentris to the project, who will help with the current reporting of our Horizon2020-funded project to the funding agency (European Commission). Great progress despite the pitfalls of the pandemic and the administrative hurdles connected to the clinical trial!

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Personalise and maximize pain relief for individuals suffering from chronic pain

Summary Statement

10 institutions in Europe and the USA collaborate for the next 5 years to help patients suffering from chronic pain. QSPainRelief aims to develop effective drug combination treatments for the improved relief of chronic pain. A quantitative systems pharmacology (QSP) mathematical modelling approach will be used to identify and validate more effective therapeutic interventions by smart combinations of existing drugs. The ultimate goal is to personalise and maximize pain relief for individuals suffering from chronic pain while diminishing side effects.

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Objectives

  • Consolidating cutting-edge treatment models for chronic pain
  • Summary Statement
  • Validating novel combinational therapies preclinically in vitro and in vivo
  • Conducting clinical studies to detect functional biomarkers
  • Improving the clinical guidelines for pain relief in stratified patient groups
  • Personalising pain relief treatment for each patient
  • Improving the scientific understanding of chronic pain regarding age, sex, disease and genetic factors

Impact

  • Novel concepts of combinational pain relief therapies
  • Improved efficacy and acceptability in the clinic
  • Effective stratification of patients with respect to age, sex, disease and genotype
  • Personalised treatment with unswerving benefits for patients
  • Unique knowledge gain and innovation opportunities