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News

17 November 2024

QSPainRelief PhD students receive awards at SIF Congress

We proudly congratulate the consortium’s early career scientists (ECS), Elisabetta Cuna (PI: Andrea Bedini) and Chiara Cimetti (PI: Monica Baiula) from partner UNIBO, for being awarded one of approximately 15 “Best Oral Communication” and “Best Poster” awards, respectively, at the National Congress of Italian Society of Pharmacology (Società Italiana di Farmacologia – SIF) that took place in Sorrento, Italy, from 13-16 November 2024. Title of Elisabetta’s oral presentation: “Quantitative Systems Pharmacology platform to predict optimal drug combinations for chronic pain: Evaluation of morphine and pregabalin potential interaction in neuronal cell models“. Title of Chiara’s poster: “In-vitro investigation of Mu opioid receptor (MOR) interfacial residues computationally predicted to have a role in MOR/cannabinoid receptor 1 (CB1) heteromerization and crosstalk basally and in response to morphine treatment.”

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Events

9-11 December 2024

Upcoming 6th General Assembly (GA) Meeting in Bologna, Italy

Preparations for the 6th GA Meeting in Bologna, Italy, from 9-11 December 2024, are in full swing. The local host, partner UNIBO, the project coordinator Prof. Liesbeth de Lange (ULEI), and the organising team from concentris are looking very much forward to welcoming the consortium at the Welcome Dinner on Monday evening, starting into Tuesday morning with an early career scientist (ECS)-dedicated programme, including short talks by all ECS and two Masterclasses, and then proceed with integrative work package (WP) sessions on Tuesday afternoon and Wednesday. We are also expecting fruitful outcomes from the 3rd Impact and Innovation Board (IIB) Meeting and helpful feedback from our Scientific and Ethical Advisory Board (SEAB) members Nadia Malliou (president of Pain Alliance Europe, PAE), Dr. Jan Freijer (Independent Consultant), and Dr. Petra Bloms-Funke (Managing Director at BlomsFunkeResearch GmbH).

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Resources

Personalise and maximize pain relief for individuals suffering from chronic pain

Summary Statement

10 institutions in Europe and the USA collaborate for the next 5 years to help patients suffering from chronic pain. QSPainRelief aims to develop effective drug combination treatments for the improved relief of chronic pain. A quantitative systems pharmacology (QSP) mathematical modelling approach will be used to identify and validate more effective therapeutic interventions by smart combinations of existing drugs. The ultimate goal is to personalise and maximize pain relief for individuals suffering from chronic pain while diminishing side effects.

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Objectives

  • Consolidating cutting-edge treatment models for chronic pain
  • Summary Statement
  • Validating novel combinational therapies preclinically in vitro and in vivo
  • Conducting clinical studies to detect functional biomarkers
  • Improving the clinical guidelines for pain relief in stratified patient groups
  • Personalising pain relief treatment for each patient
  • Improving the scientific understanding of chronic pain regarding age, sex, disease and genetic factors

Impact

  • Novel concepts of combinational pain relief therapies
  • Improved efficacy and acceptability in the clinic
  • Effective stratification of patients with respect to age, sex, disease and genotype
  • Personalised treatment with unswerving benefits for patients
  • Unique knowledge gain and innovation opportunities

Project partners