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News

17 November 2021

Dutch translation of QSPainRelief info brochure now available

The Dutch (NL) translation of our QSPainRelief info brochure is now available on the DOWNLOADS page (and on the project’s intranet). You can access and download a web version and a print version. Thanks a bunch, Liesbeth (ULEI), for providing the translation! We hope the brochure will be well-received by Dutch-speaking individuals participating either in the clinical or the healthy-volunteer trial.

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Events

13-15 December 2021

3rd QSPainRelief GA Meeting

We are very much looking forward to seeing the QSPainRelief team and SEAB members & hearing about the project’s progress during our next GA Meeting from 13-15 December – alas not, as hoped for, in-person in Munich, but again online via Zoom. Check your inbox for updates! Although the pandemic once more crossed our plans for a f2f meeting, we are not giving up the hope to see each other in person again next year.

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Personalise and maximize pain relief for individuals suffering from chronic pain

Summary Statement

10 institutions in Europe and the USA collaborate for the next 5 years to help patients suffering from chronic pain. QSPainRelief aims to develop effective drug combination treatments for the improved relief of chronic pain. A quantitative systems pharmacology (QSP) mathematical modelling approach will be used to identify and validate more effective therapeutic interventions by smart combinations of existing drugs. The ultimate goal is to personalise and maximize pain relief for individuals suffering from chronic pain while diminishing side effects.

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Objectives

  • Consolidating cutting-edge treatment models for chronic pain
  • Summary Statement
  • Validating novel combinational therapies preclinically in vitro and in vivo
  • Conducting clinical studies to detect functional biomarkers
  • Improving the clinical guidelines for pain relief in stratified patient groups
  • Personalising pain relief treatment for each patient
  • Improving the scientific understanding of chronic pain regarding age, sex, disease and genetic factors

Impact

  • Novel concepts of combinational pain relief therapies
  • Improved efficacy and acceptability in the clinic
  • Effective stratification of patients with respect to age, sex, disease and genotype
  • Personalised treatment with unswerving benefits for patients
  • Unique knowledge gain and innovation opportunities