View topic-related background literature as well as publications of the QSPainRelief consortium itself. Once new publications became available, we listed them here (and strive to do so also after the end of the project). Open access listings are linked directly to the full-text version. All others lead to the respective journal repository or publisher. Consortium members were asked to fill out the manuscript synopsis template when planning a new publication and send it to the PMO. For more QSPainRelief dissemination materials, please go to DOWNLOADS.
QSPainRelief publications (total count: 25)
2025
- Bakker WA et al. (2025). Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects. ACS Pharmacol Transl Sci, 8(3): pp. 819–830. PDF
- Budda D et al. (2025). Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis. Eur J Pharm Sci, 212: 107195. PDF
- Gousset S et al. (2025). Novel approaches to investigate central sensitisation: from experimental models to clinical perspectives. PhD Thesis, Université catholique de Louvain, Louvain-la-Neuve, Belgium: pp. 1 -233. PDF
- Gousset S et al. (2025). Preoperative susceptibility to developing secondary hyperalgesia is associated with post-thoracotomy pain at 2 months. Eur J Pain, 29: e4768. PDF
- Gülave B et al. (2025). Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution? J Pharmacokinet Pharmacodyn, 52, 11. PDF
- Gülave et al. (2025). Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model. Pharm Res, 42, 281–289. PDF
- Ortiz et al. (2025). A mathematical formalism to quantify drug-target residence time. Biochem Pharmacol, 239: 117037. PDF
- Rinaudo CM et al. (2025). Navigating the biopsychosocial landscape: A systematic review on the association between social support and chronic pain. PLoS One, 20(4): e0321750. PDF
- van Valkengoed et al. (2025). Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly? J Pharmacokinet Pharmacodyn, 52: 16. PDF
2024
- Bertayli M et al. (2024). PK-PD model of morphine, pregabalin and their combination to assess the opioid-sparing effect. Population Approach Group Europe 2024 (PAGE Conference 32): Drug/Disease Modelling – CNS: Poster Abstract No. 11143. PDF
- Budda D et al. (2024). Non-linear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix. Br J Pharmacol, 181 (20): pp. 3856-3868. PDF
- Ortiz AJ et al. (2024). Time-dependent ligand-receptor binding kinetics and functionality in a heterodimeric receptor model. Biochem Pharmacol, 225: 116299. PDF
2023
- Del Mar Cajiao-Manrique M, Maldonado R, and Martín-García E (2023). A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction. Front Pharmacol, 14: 1143365. PDF
- Del Mar Cajiao-Manrique M et al. (2023). THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model. Front Psychol, 14: 1148993. PDF
- Díaz O et al. (2023). Allosteric binding cooperativity in a kinetic context. Drug Discov Today, 28 (2): 103441. PDF
- García-Blanco A et al. (2023). Role of CB2 cannabinoid receptor in the development of food addiction in male mice. Neurobiol Dis, 179: 106034. PDF
- Gülave B et al. (2023). Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies? Eur J Pharm Sci, 187: 106482. PDF
- Saleh MAA et al. (2023). Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice. Pharm Res, 40: pp. 2555–2566. PDF
2022
- Cabañero D et al. (2022). Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain. Bio Protoc, 12(5): e4348. PDF
- Díaz O, Renault P, and Giraldo J (2022). Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation. ACS OMEGA, 7(42): pp. 37873–37884. PDF
- García-Blanco A et al. (2022). miRNA signatures associated with vulnerability to food addiction in mice and humans. J Clin Invest, 132(10): e156281. PDF
- Mayneris-Perxachs J et al. (2022). Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function. ISME J, 16(9): pp. 2181–2197. PDF
2021
- Renault P and Giraldo J (2021). Dynamical Correlations Reveal Allosteric Sites in G-Protein-Coupled Receptors. Int J Mol Sci, 22: 187. PDF
- Ricarte A, Dalton JAR, and Giraldo J (2021). Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns. J Chem Inf Model, 61 (3): 1251–1274. PDF
2020
- Bruzzese A, Dalton JAR, and Giraldo J (2020). Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation. Sci Rep, 10: 19942. PDF
Background reading
- Kirouac DC et al. (2019). Reproducibility of Quantitative Systems Pharmacology Models: Current Challenges and Future Opportunities. CPT Pharmacometrics Syst Pharmacol, 8 (4): 205-210
- Scholz J et al. (2019). The IASP Classification of Chronic Pain for ICD-11: Chronic Neuropathic Pain. Pain, 160 (1): pp. 53-59
- Mills SEE et al. (2019). Chronic Pain: A Review of Its Epidemiology and Associated Factors in Population-Based Studies. Br J Anaesth, 123 (2): pp. e273-e283
- O’Brien T et al. (2017). European Pain Federation Position Paper on Appropriate Opioid Use in Chronic Pain Management. Eur J Pain, 21 (1): pp. 3-19
- Glare P et al. (2019). Transition from acute to chronic pain after surgery. Lancet, 393 (10180): pp. 1537-1546