View topic-related background literature as well as publications of the QSPainRelief consortium itself. Once new publications are available, we list them here. Open access listings are linked directly to the full-text version. All others lead to the respective journal repository or publisher. Consortium members, please fill out the manuscript synopsis template when planning a new publication and send it to the PMO. For QSPainRelief press releases please go to DOWNLOADS. To receive our project newsletter please subscribe here!
QSPainRelief publications (total count: 14)
2024
- Budda D et al (2024). Non-linear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix. Br J Pharmacol, online ahead of print. PDF
- Ortiz AJ et al. (2024). Time-dependent ligand-receptor binding kinetics and functionality in a heterodimeric receptor model. Biochem Pharmacol, 225: 116299. PDF
2023
- Del Mar Cajiao-Manrique M et al. (2023). THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model. Front Psychol, 14: 1148993. PDF
- Díaz O et al. (2023). Allosteric binding cooperativity in a kinetic context. Drug Discov Today, 28 (2): 103441. PDF
- García-Blanco A et al. (2023). Role of CB2 cannabinoid receptor in the development of food addiction in male mice. Neurobiol Dis, 179: 106034. PDF
- Gülave B et al. (2023). Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies? Eur J Pharm Sci, 187: 106482. PDF
- Saleh MAA et al. (2023). Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice. Pharm Res, 40: pp. 2555–2566. PDF
2022
- Cabañero D et al. (2022). Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain. Bio Protoc, 12(5): e4348. PDF
- Díaz O, Renault P, and Giraldo J (2022). Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation. ACS OMEGA, 7(42): pp. 37873–37884. PDF
- García-Blanco A et al. (2022). miRNA signatures associated with vulnerability to food addiction in mice and humans. J Clin Invest, 132(10): e156281. PDF
- Mayneris-Perxachs J et al. (2022). Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function. ISME J, 16(9): pp. 2181–2197. PDF
2021
- Renault P and Giraldo J (2021). Dynamical Correlations Reveal Allosteric Sites in G-Protein-Coupled Receptors. Int J Mol Sci, 22: 187. PDF
- Ricarte A, Dalton JAR, and Giraldo J (2021). Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns. J Chem Inf Model, 61 (3): 1251–1274. PDF
2020
- Bruzzese A, Dalton JAR, and Giraldo J (2020). Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation. Sci Rep, 10: 19942. PDF
Background reading
- Kirouac DC et al. (2019). Reproducibility of Quantitative Systems Pharmacology Models: Current Challenges and Future Opportunities. CPT Pharmacometrics Syst Pharmacol, 8 (4): 205-210
- Scholz J et al. (2019). The IASP Classification of Chronic Pain for ICD-11: Chronic Neuropathic Pain. Pain, 160 (1): pp. 53-59
- Mills SEE et al. (2019). Chronic Pain: A Review of Its Epidemiology and Associated Factors in Population-Based Studies. Br J Anaesth, 123 (2): pp. e273-e283
- O’Brien T et al. (2017). European Pain Federation Position Paper on Appropriate Opioid Use in Chronic Pain Management. Eur J Pain, 21 (1): pp. 3-19
- Glare P et al. (2019). Transition from acute to chronic pain after surgery. Lancet, 393 (10180): pp. 1537-1546